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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1252081ac27ac4e21ebf3c17edf435cadaecc53e776eff59fd25232268432be3' 
  AND token = 'LkqQWbkH2Q39Jwn+VjMuw1k3hvynSZ+jsBc4dMXWIU0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}