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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '94b44dbb853ee7b71105a409bc1cfa5aaad7da1e3981d08caf83c683e2340bac' 
  AND token = 'kRJjrfe+LwfEn6EjDMIJW5KHCpyrl8OEczAw7rs8kT8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}