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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16600dd00c8a109572383d7525c473005586b7751f881d4e71111d95255407b5' 
  AND token = 'yvMKU50f7bL2L1Ig/mOVZH8cR3FkV2BfqAqw0WW5mCU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}