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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65a5b8b122efd37f69b0974d22160911283bc458f0b3d093fed016435fcb2fac' 
  AND token = 'GzjaLoCQoGE3wU2TVoBQeDDPAVVkkUkus67VbEl44vE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}