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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a80b87fa44782aa20eaba10d322c6cdfc6de814ae8a3d1a9f6d7d38a3b27bc0e' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}