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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49fdc954a5c4a0318c1d62a44a69d520f8da05517da3f276bc21efefd62b56e9' 
  AND token = 'zPAMDsMmSh4UrCE2TcOrl3OwDj+gT8sveWPQnpZ8GO4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}