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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3eac66b9db9546442b92169a147bfd68977800990ba7050aeb7d45da9f5a9490' 
  AND token = '3YHGYaOqqAb6sOt7rrhFfhkPZhTHArDc2QfjpIH0o6A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}