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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '220b4ac75181de43b7f7ef61c06f326ab55bce33f304a296e4c1d5b412300421' 
  AND token = 'eVMODg1Ip4cx7c9c3wWbgYTXkcwtTl8Hl0p9pYluLwc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}