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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7657f14e16c7c4f794a956bddc4d837034779b91f4b9e970927a4b024f480c1b' 
  AND token = 'BD6mJfttRwlS1Qgcoknw0Vg8jeY4GZDWoA1MRF0GJqI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}