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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a0450106436064784d853099ab77239f97ad8075dfac12195d1ec34e4e1ac02c' 
  AND token = 'fFNi2BQo0o3darVEUk9CL0OM3fs1ofx0oZHEeNpE9TA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}