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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78d6380862fe36dc0ef161355c4a1ef6627b89f2400c313b121d3e9e72802f1c' 
  AND token = 'oV0VRWzqYa1W2pmcJIpp2+J1tGBhTX0u5EojCbIMmQ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}