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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2216253a1a5072988f8aaf58b052e58dc1fc5676aee66fcb4fc8b0d47f4a97a9' 
  AND token = 'er1IXvAY8aiCj2e+Bt/Brh5ncz16HOj6C61nZ+yqjSY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}