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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3118d461a0c32fe385c1ae672f01a7e0071c9ee515067d517b70cc5af7e3a018' 
  AND token = 'gLM8uYcKhaTiF+B3ujfdimTH6eDn1Qta+TuAlZf6hzE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}