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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c49b4e18040d9abc7b4bf88895bbb09457aed5b7e82140f170946f1de16f20b' 
  AND token = '4/cWPIM/kVLyA0GF14ZV0Z6uJfIj/y3OaSyMC6jPEiQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}