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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e523a6af13c7c3b21d9ce585acb44e080523fcc0b37a2e56dceb0228f3d7e60b' 
  AND token = 't2IQiBiHGrXtgYZ+/KrtDmlMXMyWvpbb0efQmcT99g8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}