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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0a378a2c14b5b3fa404dc668b4d796aa19af776b6f4f5236eb06a8cb5fe78815' 
  AND token = 'pvdN08xW/Kdvu+4OU1TIfK4+JErZjQvc0j8AFkMFsPY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}