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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48a9dc80ce7c8d498b63286476e8bd2cf0492d2359328c8e0ef323e46d2e74c3' 
  AND token = 'v5MansA3tiLhkwY188c9pLhUZG1vO+f+wzRwxfebhqI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}