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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f5f5ea652e66176579d9200bc10d561d545de6e34d22dc5b6ce6d1a818dfb5a4' 
  AND token = 'tRWD4XMZFBt2XIL+gZU0RncpZ2qkSF6x2ExVG0a4rLI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}