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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af40a8d778a581be2b0266a4291fcd5bcb3c2d9f1a14cd4903618405cb002b11' 
  AND token = '/mYwt4mOSwyL3RCgBFH7wY5dC+frt2GzhoCkmy0OsSQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}