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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4aedc72255a5637c71e82f34a3cdf9741eea4d511e7e3378a31c43000a7a2b4' 
  AND token = 'xqIq0nuPxCu/0H5xDgieYaG7wX4Z1DcmgHZOSaqwsqY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}