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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33f8d57b3c6cd3589f830340b73d1407eb75540a32288a2800e39b6fa2e86c73' 
  AND token = 'wfsHebVx1mec/86GRs+S494OwfNgdvRFIaMjck8p9xE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}