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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a225ba4c10fd6dc060bfe659f1e1d4ddc287e2ff19cd9f83bd023f34e34802a6' 
  AND token = 'EWubAOWdEXibr/lfiq+6EaZO5AULbe1a8zERVKxaUt4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}