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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a4463740dd5c18873beee7d9e9f0daca55af35163c35090c714c163086503d55' 
  AND token = 'gu9xxWRa+htKGlb4C33F0nXc551MGl6tuVVjVLEHxUA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}