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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec40c605ffba6f36abc1ccf6fc4b9fe7c4da1943ad38f478fb69e8e3d11435fa' 
  AND token = '+ihux1dvK3DPkRA/KXmeA8aKYzLeB+9HVzOpXpIFJRo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}