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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fb8cb7d347adf05faafd0c2c449513a13d0e7eb12218bcaab13325d993e36122' 
  AND token = 'myFV+VnQjSPneMFZpD71b1IC61espy2KUl2bU0bsy9U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}