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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12de6a60b085b16005d2c5434d419e2426dec81baca37fb5e2c455f1697a649e' 
  AND token = '22O9m/Q15XOYXw/ypuDxVj59mRg5PPddVO2u0HuGCY0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}