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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45ef2e3c802512d7602ae6ad59d915b5f191150283a980c1eb206a32f0a95dcf' 
  AND token = '7p+aLxRkxOCB+L0g+KJ0JVECKgrxh7pI9CjxZVjbNZA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}