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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0221f28349ace8fdd8cc4716c3fe57b6aa12f14af3327005f0acce15a6d3bf33' 
  AND token = 'I/iM0MUvJcyk0IFRCkBM1bSoYub+g8vS8KsmcMlgRu4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}