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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '166adb7b159498b6e3db05e23906ca624ce0b933c53dcaca25a2d0a9646cb429' 
  AND token = 'KG+FiJtp+I6cpolcZ02q6Nmzw0+2dGkS9x8wrxRIUZs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}