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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f3375d22d87d634fd657592ee1904ef9d321818c00d0e52cde8ef1ad4edd81e7' 
  AND token = 'GdXmzfBMQbAGESGx7XyFqHFkD4g2FCoG6LV1sUrQ4yc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}