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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8af90b03b5e0d248e3bb23ce66b2c3c6864b06d6a34ecd272241111df489b104' 
  AND token = 'fXXoFYCbGDN5OpUh03oXuaDdsM8a1PZsWz+UzW1NcWg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}