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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '280556e7a069965528799f5daac68bb30a473928b5bd5763a6a50d6c17b9e7a5' 
  AND token = '2FZE/hQXHudl7wkM1XxhclHV33iYkheb+qv3khG6Y3o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}