SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72395bd07464e7b041d89aea60fb7ae1a7f2870a59ab0b2717400e2b0398c1e9' 
  AND token = 'pUpBlqo+DYNZXwt+A799hIlRn4RMOfifJ6+KTaZfTUs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}