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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80d82c5cc358b10543fe5b658ed4c2cb0c8272b203fe89ff46a53c15ab2f370a' 
  AND token = '2/fMaDvL016i+2TCHBbBFvx+LfYsxZpsbrY6ItnCd4s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}