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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ec69d2feac20345a126226510d4d1728162b82cb41d9b9bf69359d81a33fccd' 
  AND token = '0pFvLWVDNJbOWlJ6jo/i90PJ08z0cvXiy0RSFY8JKYI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}