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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2043f18ec1d629e685616bcaee44b7d58c6fdaf0c3bb463f2cd7c7e78f9fd364' 
  AND token = '2FdxhVMC1ZWNEYynLSwssXaEQC93pncdlhfnWxaya4E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}