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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f763c345fe2a50ecb0e2c13db80710aef91a80e09b54fdda77b09664f91496d' 
  AND token = 'ZTFiSF3+J/vORHdpk/5h4Mpeyxa80Cz2nBArGXSRRD0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}