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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721ec3bb18b1caf13890d09b4bf529cf28a10816c07a3b784226cb6f05e0c887' 
  AND token = 'UCguyyVu38kXqlOLndrJhFeE8XhnM9Aq9+nNKrBHBPU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}