SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a00ddc15c311b1c75358ce9d05a1d9b8343c6dbbed24c8111e537daa7362129' 
  AND token = 'ZCTh/OrPC3KZpx6bpx6wyRnnRlU1SbqRiS05IHg5sY8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}