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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '889f321741622cf8d9fed8e09638d8ca5d252279005c57cb172f29b7b65038f5' 
  AND token = 'RMnLgjA5jwW7cHn8FGZWj+sMyS3reiP9mLXBHDDuEQY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}