SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3721d47f6c2b221a862a234ef43215047d20fada570e8746f04eaef26da7e330' 
  AND token = 'YgM4hpyCuxLvWAhZeCNa1467awWGowgHf15gtCe49co=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}