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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59a6186260edcfcecd0676eb5a2fdb95f3cdb0b28ad6beb45bc3cb2da191a67d' 
  AND token = 'WJx5ElJDHmqg84TFC8wjiBxjmh1fh2t9ZmqPQVk9pOw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}