SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '850d620d75f7aaa195b994a269cd0cc68f2fb87aef790561a6c367f9cde14c73' 
  AND token = 'HTPUwaMS2mDY0rzNL54a1UJvMAtU7iz6BUeFYU0E9FA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}