SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '454ff0e4f3f0d725b4f07879e71c0782ecd0ec6768d3736a2630101c67000544' 
  AND token = 'EPRgy80M5htyQk0T9jD7IsdW1IafrER3duf9gB+KvDM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}