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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1646b236e9ee72fb71b218d33b024494630b468b26634c0c6c1d70f0f517d068' 
  AND token = 'vXbxdd1UB4A2sQqqxzfcxdKqLUq0sFr9s0yXP1b5CCQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}