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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8f76b6fb6ee2964862a891b6c9335ce9c7d4868a4fe8ad63a1641a81f5013267' 
  AND token = 'R9iiwj/NGy/jshCGx32kJPPXoY+k9wrZ4tHtXr2ERpE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}