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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f1073fd12d2b9f81c5789504dfd0a4072d9143399a767879147678a680c5f90f' 
  AND token = 'C0Tm82b9u/mGgiSDmVEx2Jf19FpUfz8FxU2TWfs+HQM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}