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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '220701f8d47ebdffea99e27552bb77cc4f151a300b742d6e8eceb370cad5d0b6' 
  AND token = 'nT6m9yAsZ7DEUkqz4AAg/lpHyJK6ylPGk+Qx0yAF++I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}