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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18e1d47645f27258c2dcf7614daf6dbaa41b225538e6c2c5d34099210bd1b2cb' 
  AND token = 'Ur7m0g0XyM17+92T8Z4EIx7FtgPdISwa0zITLf5iDfQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}