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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8227c3345471fa2daac192a20a3b3b7645c6cc513eb969d5e88ea9049b4d0f6d' 
  AND token = '9UHT6Pthq/0B0NABUHDmHPbYl1MVOMEWuPUXFXUEvd4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}